Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection. ![]()
0 Comments
The detachable handle is a great innovation so long as you do not lose it. It’s body frame and tactical rail location are close in size and placement to the Apollo, but it is a bit thicker and the tactical rail is twice as long as the Apollo’s. The Helios is compatible with the same Rival 12-round magazine that the Zeus, Hera, Apollo, and Atlas can use, so coming with a small magazine is not a big concern for most people. Minimalistic, but for the money, I suppose it is a decent deal. The Helios comes with a detachable priming handle (for lefties, righties, or ambidextrous people), a 7-ball magazine, 7 balls (including the display ball embedded in the standard packaging), and 2 Rival flags (1 red and 1 blue). In fact, one could argue that the Helios is the Apollo MK2. The closest related blaster to the Helios happens to be the Apollo. The blaster was designed for teenagers, after all, and it is still easier to operate over the awkward top-priming Apollo. Younger “Nerfers” should have a harder time using the blaster but I believe the new auto-return priming “bolt” handle should help a bit with the overall operation. The standard average velocity of a Nerf Rival blaster is 100 FPS, so the Helios’ velocity rating is just under the average, but just remember that for a “springer” type blaster, typically the stronger it is, the harder it will be to prime (to compress the internal spring enough to operate the blaster). My ProChrono Digital chronograph measured the speed of the Rival rounds fired by this stock Phantom Corps Helios blaster at an average of 94 feet per second (FPS). I believe there are larger (12 round?) magazines available for purchase, and while the longer magazine could extend your play, it would also protrude much further from the handle and make the blaster less compact.īased on unboxing, assembly, and a few minutes of play, I give it 5/5 ⭐️⭐️⭐️⭐️⭐️ The magazine holds 7 rounds and protrudes about 2 inches from the handle when fully inserted. Even with soft foam ammo, the sound of impact is impressive. ![]() ![]() The Helios fires with a speed and power that I did not expect, given my previous experience with Nerf blasters. A testament to its durability perhaps? I suppose time and useage will tell. While the instructions to clear it seem pretty simple and straightforward, the actual process was challenging in that I had to use a bit more force than I assumed the blaster primer could handle in order to clear the jam. I did manage to get a jam after a few minutes of use. Once it is, just aim and pull the trigger. An indicator on the side will show that the blaster is primed. Flip the trigger lock, slide the priming bolt back and release it. All I had to do was slide the priming bolt into the side of the blaster (can be inserted on either side, for righties and lefties alike), load the magazine, and slide the magazine into the handle. This Helios XVIII-700 was easy to assemble. When I first saw a Rival blaster up close, my inner child had me feeling both nostalgic and eager to get one of my own. Nerf has definitely stepped their game up since I was a kid. ![]() A street tree shall be considered adjacent to property if the tree would be within the lateral boundaries of the property if those boundaries were extended to meet the nearest portion of roadway.Īnimal at large – An animal off or outside the premises of the owner or person in charge of the animal, not restrained by a rope, line, leash, chain, or other similar means, or not under the immediate control, restraint, and command of the person or its owner.īicycle Path – The portion of the public right-of-way that is not part of a roadway and is designated by official signs or markings for use by persons riding bicycles.Ĭity representative – The mayor or the mayor’s designee responsible for representing the City’s interest in a nuisance abatement proceeding.Ĭosts – The expense of removing, storing, or disposing of nuisances, including a charge of 20 percent of the expense for administrative overhead.ĭiscarded vehicle – A vehicle that is not operable on a public street, wrecked, dismantled, partially dismantled, abandoned or junked or major parts of discarded vehicles including, but not limited to, bodies, engines, transmissions and rear ends. įor the purposes of this ordinance, the following mean:Īdjacent – Nearby or close to. Animals at large may be taken into custody by the City and disposed of in accordance with the procedures provided by the Code or other City ordinance for disposition of personal property or for the impoundment of dogs. 2233, 1983)Įxcept for animals of the species Felis Catus (domestic cat), no owner or person in charge of an animal shall permit the animal to be at large. ![]() Further, at any such trial, defense counsel shall not be provided at public expense. At any trial involving an infraction, the City Attorney shall not appear unless the Defendant is represented byĪn attorney. ![]() The City of Ashland shall have the burden of proving the infraction by a preponderance of the evidence and the Defendant may not be required to be a witness in the trial of such infraction. The trial of any infraction shall be by the Court without a jury. The penalty for committing an infraction shall be a fine not to exceed $500 however, each and every day during any portion of which any infraction is committed, continued or permitted by any such person, is a separate violation subject to a separate fine of $500.00 and such person shall be punished accordingly. Provided, however, that the City Council may, in its discretion, designate certain areas within the City where dogs may be permitted to run free while under the owner’s or keeper’s control.Īny dog that is vicious or dangerous to the safety of persons must be confined by enclosure or a leash to property of its owner or keeper.Īny dog not confined to property as set forth above in this chapter and which is on either public or private property must be on a leash not longer than six (6) feet in length.ĭogs not on private property as described above must always be attended by their owner or person having the custody of such dog and, it shall be unlawful for any person to tie or permit to be tied or remain tied a dog or any other animal to any tree, hydrant, railing, or other object on the public property of the City of Ashland.Īny person who violates any provision of this chapter shall be punished as set forth in Section 1.08.020 of the Ashland Municipal Code.Ī person who commits an infraction by violating designated provisions of the Ashland Municipal Code shall not suffer any disability or legal disadvantage based upon conviction of crime. ![]() City, County Ordinances in Oregon Governing Dogs At LargeĪll dogs must be confined by fence, leash, or obedience training to the property of the person owning, harboring or having the charge, care, control, custody or possession of such dog however, it shall be permissible for a dog to be confined by fence, leash or obedience training to the property of another if such other person has given express permission. ![]() Haloid eventually became Xerox Corporation in 1961. ![]() After consulting a professor of classical language at Ohio State University, Haloid and Carlson changed the name of the process to " xerography", a term, coined from Greek roots, that meant "dry writing." Haloid called the new copier machines "Xerox Machines" and, in 1948, the term "Xerox" was trademarked. Haloid felt that the word "electrophotography" was too complicated and did not have good recall value. In 1947, Haloid Corporation (a small Rochester, New York-based manufacturer and seller of photographic paper) approached Battelle to obtain a license to develop and market a copying machine based on this technology. Over the next five years, the institute conducted experiments to improve the process of electrophotography. In 1944, the Battelle Memorial Institute, a non-profit organization in Columbus, Ohio, contracted with Carlson to refine his new process. Between 19, Carlson was turned down by over 20 companies, including IBM and General Electric-neither of which believed there was a significant market for copiers. People did not see the need for an electronic copier. At the time, multiple copies were most commonly made at the point of document origination, using carbon paper or manual duplicating machines. Carlson tried to sell his invention to some companies but failed because the process was still underdeveloped. After the slide was removed, a mirror image of the words remained. The words "10-22-38 Astoria" were written on a microscope slide, which was placed on top of more sulfur and under a bright light. He made the first photocopy using a zinc plate covered with sulfur. Carlson used his kitchen for his " electrophotography" experiments, and, in 1938, he applied for a patent for the process. This motivated him to conduct experiments with photoconductivity. Carlson, who was arthritic, found this a painful and tedious process. His job at the patent office in New York required him to make a large number of copies of important papers. High-end color photocopiers capable of heavy-duty handling cycles and large-format printing remain a costly option found primarily in print and design shops.Ĭhester Carlson (1906-1968), the inventor of photocopying, was originally a patent attorney, as well as a part-time researcher and inventor. ![]() Low-end machines that can copy and print in color have increasingly dominated the home-office market as their prices fell steadily during the 1990s. During the 1980s, a convergence began in some high-end machines towards what came to be called a multi-function printer: a device that combined the roles of a photocopier, a fax machine, a scanner, and a computer network-connected printer. While there have been predictions that photocopiers will eventually become obsolete as information workers increase their use of digital document creation, storage, and distribution and rely less on distributing actual pieces of paper, as of 2015, photocopiers continue to be widely used. Photocopying is widely used in the business, education, and government sectors. Copiers can also use other technologies, such as inkjet, but xerography is standard for office copying.Ĭommercial xerographic office photocopying gradually replaced copies made by Verifax, Photostat, carbon paper, mimeograph machines, and other duplicating machines. The toner is then fused onto the paper using heat, pressure, or a combination of both. Most modern photocopiers use a technology called xerography, a dry process that uses electrostatic charges on a light-sensitive photoreceptor to first attract and then transfer toner particles (a powder) onto paper in the form of an image. ![]() A Xerox digital photocopier in 2010Ī photocopier (also called copier or copy machine, and formerly Xerox machine, the generic trademark) is a machine that makes copies of documents and other visual images onto paper or plastic film quickly and cheaply. For other uses, see Copier (disambiguation). You MAY NOT distribute the brushes in any way. firealpaca firealpaca brush custom brush I want y'all to know that this was the post I hit publish on before tumblr nuked me lmao but anyway I hope this was worth the long wait anon sksk also please understand that you'll have to draw in the ends of the braids yourself 'cause y'know the brush is limited to what it can do lol EDIT: tumblr janked up the braid order to match the examples. You MAY NOT claim these brushes as your own. You MAY NOT repost these brushes anywhere. You MAY show me your art using this brush! I'd love to see it.~ You MAY direct your friends to this brush so they can download it. You MAY use it in for profit work so long as I am properly and CLEARLY CREDITED You MAY use it for public and private use. Thanks so much guys! Please feel free to leave requests, questions, or comments below! You may think 'What I havent seen them' Diagram:FireAlpaca 1.8.11 Preset Brush. Some of those unique brushes are Marker, Fluffy, Symmetry Rotate, Polka Dot, etc. Super basics Create a canvas for drawing First, start FireAlpaca and create a canvas Here is the basic steps to create a new file. Here are the explanation of when Autosave takes place and how data gets recovered. This is an unofficial, fan-based subreddit for FireAlpaca. Autosave function has been equipped since the version 1.7.0. Right side: Two 'Flame' brushes (Or texture brushes.Theyre fun to mess with. (Preview being edited) Left side: Three New Bokeh brushes. Some brushes I had been making for myself I figure I should share. Post questions, creations, share brushes or settings, or any other stuff related to FireAlpaca. bokeh brush brushes flame flower light simple sparkle star firealpaca. FireAlpaca is free digital painting software for Windows, macOS, and now Linux. If you like it, please think of donating via points on my profile, or via my paypal. FireAlpaca has Preset Brushes already equipped in the application. FireAlpaca Free digital painting software for macOS and Windows. Anyways, enjoy! And tell me what you think, please! Also, for those of you wondering - I will be setting up a PS version of these brushes ASAP, I just need to borrow my roomies copy of photoshop. My first monthly brush pack! I was going to upload this on saturday, since it was right after my birthday but then we had some family problems and I totally forgot! I tried to make the preview a little more professional to make up for it. Lots of high resolution goodies for graphic design including textures, photoshop brushes, seamless patterns and more. A friend of mine saw my art, and loving the pop art pattern I used, wanted me to upload my brushes This is pretty much all I use besides soft brushes so here it is Pop art, Grid, and Cool Kid I use as 'pattern' brushes and Stars/Skin Texture works best set to 'scatter. IF YOU CANNOT SEE EACH INDIVIDUAL ALPHA AND SETTINGS PNG, YOU WILL NOT BE ABLE TO INSTALL THEM! THESE BRUSHES WORK WITH ANY PROGRAM THAT CAN USE ALPHA BASED BRUSHES, BUT THE SETTINGS INCLUDED ARE DESIGNED TO WORK WITH FIREALPACA. brush skin patternbrushes brushes pattern stars texture firealpaca. IF YOU ARE HAVING TROUBLE INSTALLING THESE BRUSHES AND YOU CANNOT SEE THEM WHEN YOU ACCESS FIRE ALPACA, TRY FIRST TO UNZIP THEM ONE MORE TIME. These kept me busy when I was having stressful days.Commission Prices || Resources || FAQ || Etsy Shop These brushes were quick and silly things that I didn't have to research or anything. I just don't have a lot of time to make specific brushes that will take a lot of editing time and research. I will be opening requests again in the next two months. My recommendation for uploading these brushes: Change the brush type to "Pattern" and the only box check-marked is "Use Foreground color" the brush is made with the link in the center so when it makes its pattern it all looks right. These were made to be pattern brushes at 100 pixels and 200 pixels. ![]() This is all except for the Fence Brushes. I may or may not have been watching anime before drawing. Many of these I use multiple settings for, so I have no "Here is how you use this brush!!"įor the Explodokills brush: This one was 100% for giggles and smiles. These brushes have been designed by a number of artists on DeviantArt and are currently free for download. More personal brushes I've been making over the past month or so. First, click the 'Add Brush' icon at the bottom-left of Brush Window. Here is the basic way to create a new brush 'Add Brush'. If you want to create your own unique brush, you can create a new brush manually. *description (sorry for the overlook in the picture. FireAlpaca is equipped with mlutiple of Brushes as default. I had just finished two weeks or 12 hour days. 1.5.1 Light Height : 70 ( Light source is located in the center of the canvas ) 1.5.2 Light Height : 10 ( Light source is located in the center of the canvas ) 1.6 Interval. Semi-Recent, but quick, video: youtu.be/1UKc54c7Lyc?t=7m25s(Sorry if I sound rude or anything. 1.3.1 Specular : 020406080100 ( Diffuse : 50 ) 1.4 Sharpness. Here is a tutorial someone made for the rest: fav.me/d7suqzj Hit "Download: under the favorite button. It's the perfect relaxing, no-stress gift package, and includes. 16 of 24.Image Credit: Sunday Scaries Make your dad's Father's Day weekend with this bundle from San Diego-based brand Sunday Scaries. Using thin string or embroidery floss, tie a triple knot around one nail and begin weaving string diagonally from nail to nail to fill in the centers of the letters. From $60 at Book of the …Tap nails every 1⁄2 inch around the perimeter of each letter, then remove the paper. For $60 every three months, the service curates five new reads monthly, and your dad will get to choose one new book from the roster. Instead of entering your local bookstore and being overwhelmed with all the options for your last-minute Father’s Day gift, consider Book of the Month. This Father's Day, get him what he really wants - from a cool new TV stand for his game room to practical items for his house. ![]() Whether your dad's passion is mowing the lawn or relaxing next to the portable cooler, we've got the perfect 2023 Father's Day gifts for you to give him. See more ideas about fathers day, fathers day crafts, father's day diy.Best Father's Gifts for Every Dad at Lowe's. Best Soap Set.All kinds of homemade gifts, cards, and other ideas for Father's Day!. This puzzle -which comes in 500- and 1000-piece options-will become a family activity that everyone can enjoy. Celebrate Dad's birthday or other special date with the cover of the Times. FOR THE BOOKWORM.UncommonGoods New York Times Custom Front-Page Puzzle. When he needs new flowers, to repair a leaking pipe, or to organize the garage, your handyman dad will be glad he got this. The Best Father's Day Gifts, According to 12 Real Dads Including a wine refrigerator, Smythson notebook, and one night's stay at the Edition Miami By Max Berlinger painless shopping With so many DIY projects and so little time, this e-gift card from Lowe's is just the thing the dad who's always fixing, crafting, or gardening needs this Father's Day. With a 96-foot detection and flash range, half-second trigger speed, and ability to switch between cellular providers, this is the best. Tactacam Reveal X Pro Cellular Trail Camera. Fashion Father's Day Gift Guide 2023: 11 Presents to Help Dad Chill Out Indulge your busy dad by equipping him to do as little as possible-in high style-with gifts like cashmere sweatpants. ![]() Here are some reasons shoppers may choose a buy now, pay later plan: Unlike the old layaway plans, however, you’d get to take the watch home (or have it shipped to you) right away. The payments are typically billed directly to the debit or credit card you used for the purchase. So if you buy a $300 smart watch, for example, you’d pay $75 down and 3 more $75 installments. Typically, these plans divide a purchase into equal installments, with the first installment due at checkout. The second type of plan - which truly is “buy now, pay later” - is what we’re going to focus on. If you are thinking about using a traditional layaway plan, the Federal Trade Commission has tips about how not to lose money when you use this method. (Walmart, for example, is getting rid of its layaway program in favor of a partnership with Affirm, a “buy now, pay later” financing company.) Because few stores still offer layaway programs, we’re not going to go in depth about them here. These might be better termed “pay now, get it later.” A retailer lets you make regular payments on an item and then hands over the merchandise once you’ve paid it off. Types of deferred billing plansįirst, let’s talk about traditional layaway plans. With the holiday shopping season approaching, it’s a good time to look at these new buy now, pay later programs: How they work and what the advantages and disadvantages are. “But these loans can turn into ‘buy now, regret later’ when consumers have trouble getting refunds, making returns, or keeping up with payments and get hit with unexpected fees and penalties.” “Millions of shoppers are turning to buy now, pay later plans as a convenient way to obtain credit and manage expenses,” said Chuck Bell, advocacy program director for Consumer Reports. ![]() Photo: Deposit Photos Buy now, regret later? ![]() Terms of Use and Privacy Policy and Safety Information / Your California Privacy Rights are applicable to you. ^ Back to Top ^ © 2023 ESPN Internet Ventures. Houston returns home to face the Los Angeles Angels, with Justin Verlander (6-6) taking the mound for the Astros against Reid Detmers (2-8). Kyle Gibson (11-6) starts for Baltimore on Friday night against Seattle's Luis Castillo (7-7). The Orioles recalled RHP Joey Krehbiel from Triple-A Norfolk. Orioles: Baltimore's bullpen took a hit before the game when LHP Danny Coulombe (biceps tendonitis) went on the injured list, retroactive to Wednesday. The Orioles also had a runner thrown out trying to advance on a pitch that got away from the catcher a bit. Baltimore went 3 of 3 with runners in scoring position and had two men caught stealing. Houston left 11 runners on base, and the Orioles left zero. The game started 13 minutes late because of rain. Then, with men on first and third and two out, Frazier made a diving stop on the hardest-hit ball of the day - a sharp grounder by Alvarez with an exit velocity of 115.2 mph, according to Statcast. O'Hearn made a nice catch before slamming into the wall in left on a drive by Jeremy Peña. Houston was unlucky not to score in the fifth. Rutschman made it 3-1 with a run-scoring single in the sixth after McCann doubled. Urías tripled to lead off the Baltimore third and scored on McCann's single. Houston fell to 2 1/2 games behind first-place Texas in the AL West. ![]() The previous sweep against Baltimore was at Detroit from May 13-15, 2022.īaltimore took a three-game lead in the AL East over Tampa Bay when the Rays lost to St. Louis Cardinals set the record of 124 from 1942-44. That's the fifth-longest streak in major league history - according to information from the Elias Sports Bureau distributed by the Orioles - and the longest since the St. The Orioles have gone 76 straight series of at least two decisions without being swept. Mauricio Dubón blooped an RBI single in the eighth for Houston, but Yannier Cano was able to work out of that inning. Hunter Brown (8-8) allowed five runs and eight hits in six innings.ĭiaz homered in the second for Houston, and Altuve went deep in the seventh. Now AL East-leading Baltimore heads out on a nine-game western trip with stops at Seattle, San Diego and Oakland.ĭean Kremer (11-4) allowed two runs and six hits in seven innings. Left fielder Ryan O'Hearn and second baseman Adam Frazier made terrific defensive plays for the Orioles in the fifth, and Mountcastle's two-run shot in the seventh made it 5-2. Urías made a diving stop on Altuve's grounder leading off the game, and Rutschman put Baltimore ahead with a drive to left leading off the bottom of the first. “That's a playoff atmosphere, that's a playoff team over there.”Īfter dropping the first two games of this series, the Orioles set the tone early in the finale. “Honestly, it was good for him,” McCann said. “I’m just going to check and see if they were hitting out of order, because I feel like they hit eight times a game."īautista finally retired Jon Singleton on a popup for his 31st save in 37 chances. “I think Bregman and Tucker and Alvarez, I think they hit every inning,” Baltimore manager Brandon Hyde said. ![]() Third baseman Ramón Urías made a dive for it and couldn't catch it, but he did prevent it from going all the way through and only one run came home. Tucker then drew a walk to load the bases, and Yainer Diaz followed with a line drive to the left side. Jose Altuve’s one-out double and Alex Bregman’s walk allowed the go-ahead run to come up, but catcher James McCann caught Yordan Alvarez’s foul pop, holding onto the ball as he lost his balance and fell. It was 5-3 when Bautista, who allowed a grand slam to Kyle Tucker on Tuesday night to lose that game, came on to pitch the ninth. With 5-4 win over Astros, Orioles stay sweep-less before heading to SeattleīALTIMORE - By the slimmest of margins, the Baltimore Orioles still haven't been swept in almost 15 months.Īdley Rutschman and Ryan Mountcastle homered, Félix Bautista worked through another shaky ninth inning and the Orioles extended their streak to 76 series without being swept, edging the Houston Astros 5-4 on Thursday. ![]() Improved tuning of the Opus in-band FEC (LBRR).The blend is 78% Cabernet Sauvignon, 8% Petit Verdot, 8% Merlot, 5% Cabernet Franc and 1% Malbec.Major release brings the following improvements and fixes: Of the last four vintages, the 2016 is certainly the most open-knit in the early going. I expect the 2016 will enjoy a long drinking window that will start to open relatively soon. In this mini-vertical, the 2016 most closely resembles the 2014, although it has more mid-palate sweetness and overall depth, along with a slightly darker profile. We were able to pick fairly regularly with an even flow in the cellar." The more 2016s I taste, the harder it is to fault this decadent, rich, blue and black-fruited vintage.”Īntonio Galloni - “The 2016 Opus One has turned out beautifully. "We had plenty of rain in the early part of the year," commented Opus One winemaker Michael Silacci, "followed by an early budbreak. 2016 is the vintage winemakers can't remember because it was so uneventful. 97+ Call it a hat trick: Opus One knocks it out of the park with three excellent, if very different, takes on the the last string of vintages: 2015, 20. This a very decadent expression of Opus One with a provocatively effortless harmoniousness that is truly difficult to resist. Full-bodied, super concentrated and packed with black and blue fruits, the palate is built like a brick house with firm, ripe, finely grained tannins and oodles of freshness, finishing long and perfumed. Very deep purple-black, the nose reveals profound notions of chocolate-covered cherries, crème de cassis, blueberry compote and licorice with touches of tobacco, cedar chest, Sichuan pepper, eucalyptus and violets. Robert Parker - “A blend of 77.5% Cabernet Sauvignon, 8% Petit Verdot, 8% Merlot, 5% Cabernet Franc and 1.5% Malbec, the Opus One 2016 Proprietary Red Wine was recently bottled in July and August 2018. Needs at least three to five years to come together.” Full-bodied yet linear and very refined with a very persistent finish. James Suckling - “Fantastic aromas that are complex and complete with blackcurrants, blueberries and herbs, such as basil and bay leaf. Harmonious and lively, the flavors linger to create an enduring finish with touches of dark chocolate and espresso. Juicy flavors of black cherry, blackberry and cassis flood the palate and creamy, fine-grained tannins deliver a delightfully round structure. The initial bouquet is augmented by more nuanced notes of sage, rosemary, and black olive. Winemaker Notes: The 2016 Opus One is remarkably elegant and bright offering sumptuous aromas of fresh red and blue fruit, baking spices and vanilla, and a delicate fragrance of spring florals. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Reduced doses of the DOACs are only recommended for specific patient populations (such as those with moderate/severe renal impairment in patients with NVAF). Unlike vitamin K antagonists (VKAs), the DOACs (ie, apixaban, dabigatran, edoxaban, and rivaroxaban) have a fast onset of action and are given as fixed dosing regimens without routine coagulation monitoring because of their more predictable pharmacokinetics and pharmacodynamics. Finally, appropriate monitoring of the DOACs could be of substantial benefit to patients, and there is a high potential for development in this area in the future.ĭirect oral anticoagulants (DOACs) are increasingly used in routine clinical practice for the management of several thromboembolic disorders, including the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF), and the treatment and secondary prevention of venous thromboembolism (VTE). In this paper, practical guidance and recommendations are provided for clinical situations in which the test results may aid clinical decision-making, including patients with life-threatening bleeding events, patients without bleeding but with test results indicating a risk of bleeding, for those patients with a suspected thromboembolism while receiving a DOAC, or prior to patients undergoing elective or urgent surgical procedures. Although the absence of routine coagulation monitoring is an advantage of the DOACs, measuring their anticoagulant effect and/or plasma drug levels may be helpful in certain clinical scenarios to help patient management and improve outcomes. ![]() ![]() Despite their beneficial attributes, bleeding risk (as with any other anticoagulants) is often a concern for physicians when prescribing DOACs, particularly in elderly patients, those with significant comorbidities, and other high-risk patient populations. A number of real-world studies on DOACs are ongoing, and data published so far have shown broadly similar outcomes to those demonstrated in the respective phase III trials. Direct oral anticoagulants (DOACs) have demonstrated a favorable benefit–risk profile in several thromboembolic disorders and are increasingly used in routine clinical practice. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |